Corporate News     29-Sep-23
Zydus to initiate Phase I clinical study of a novel Anti-PCSK9 candidate
Zydus Lifesciences has received permission from CDSCO, India to initiate the Phase I clinical study of its novel PCSK9 inhibitor. The Phase I prospective randomised, double-blind, placebo-controlled study will study the safety and tolerability of anti-PCSK9 product administered subcutaneously in healthy human volunteers.

Cardiovascular diseases (CVDs) are the leading cause of death globally and the World Health Organisation (WHO) estimates approximately 17.9 million people die each year due to cardiovascular diseases. Dyslipidaemia patients with high LDL-C are at a high risk of atherosclerotic cardiovascular disease (ASCVD) events, such as heart attack and stroke. A PCSK9 inhibitor will regulate the levels of LDL receptors, which are responsible for the uptake and clearance of cholesterol from the blood.

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